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127222 |
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|a Shah, Nisarg J.
|e author
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Hong, Jinkee
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|a Hyder, Md Nasim
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|a Hammond, Paula T
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|a Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth
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|b Wiley,
|c 2020-09-09T20:13:40Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/127222
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|a Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants. Copyright ©2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a NIH-NIA (5R01AG029601-04)
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|a U.S. Army Research Office (contract no. W911NF-07-D-0004)
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|a NCI grant (2P30CA014051-39)
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|a en
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|a Article
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|t Advanced Materials
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