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01671 am a22002773u 4500 |
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126215 |
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|a dc
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|a Khoo, Xiaojuan
|e author
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|a Harvard University-
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Simons, Emmanuel John
|e author
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|a Chiang, Homer H.
|e author
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|a Hickey, Julia M.
|e author
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|a Sabharwal, Vishakha
|e author
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|a Pelton, Stephen I.
|e author
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|a Rosowski, John J
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|a Langer, Robert
|e author
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|a Kohane, Daniel S
|e author
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|a Formulations for trans-tympanic antibiotic delivery
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|b Elsevier BV,
|c 2020-07-15T22:02:12Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/126215
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|a We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd.
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|a National Institute of Deafness andCommunicative Disorders - NIDCD (Grant Number R21DC009986)
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|a en
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|a Article
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|t Biomaterials
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