Formulations for trans-tympanic antibiotic delivery

• Main Authors: Khoo, Xiaojuan (Author), Simons, Emmanuel John (Author), Chiang, Homer H. (Author), Hickey, Julia M. (Author), Sabharwal, Vishakha (Author), Pelton, Stephen I. (Author), Rosowski, John J (Author), Langer, Robert (Author), Kohane, Daniel S (Author)
• Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
• Format: Article
• Language: English
• Published: Elsevier BV, 2020-07-15T22:02:12Z.
• Subjects: Article
• Online Access: Get fulltext

We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd.
National Institute of Deafness andCommunicative Disorders - NIDCD (Grant Number R21DC009986)