m⁶A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis
Despite the vast number of modification sites mapped within mRNAs, known examples of consequential mRNA modifications remain rare. Here, we provide multiple lines of evidence to show that Ime4p, an N6-methyladenosine (m6A) methyltransferase required for meiosis in yeast, acts by methylating a site i...
Main Authors: | Bushkin, G. Guy (Author), Morgan, Jeffrey T. (Jeffrey Thomas) (Author), Richardson, Kris (Author), Lewis, Caroline (Author), Chan, Sze Ham (Author), Bartel, David (Author), Fink, Gerald R (Author) |
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Other Authors: | Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC,
2020-07-07T17:28:10Z.
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Subjects: | |
Online Access: | Get fulltext |
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