Bacterial encapsulins as orthogonal compartments for mammalian cell engineering

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering

We genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzymatic reactions and size-constrained metal biomineralization. The shell protein (EncA) from Myxococcus xanthus auto-assembles into n...

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Main Authors: Sigmund, Felix (Author), Massner, Christoph (Author), Erdmann, Philipp (Author), Stelzl, Anja (Author), Rolbieski, Hannes (Author), Desai, Mitul (Author), Bricault, Sarah Jean (Author), Wörner, Tobias P. (Author), Snijder, Joost (Author), Geerlof, Arie (Author), Fuchs, Helmut (Author), de Angelis, Martin Hrabĕ (Author), Heck, Albert J.R (Author), Jasanoff, Alan Pradip (Author), Ntziachristos, Vasilis (Author), Plitzko, Jürgen (Author), Westmeyer, Gil G. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Nuclear Science and Engineering (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-07-02T20:58:19Z.
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