A Cas9 with PAM recognition for adenine dinucleotides

A Cas9 with PAM recognition for adenine dinucleotides

CRISPR-associated (Cas) DNA-endonucleases are remarkably effective tools for genome engineering, but have limited target ranges due to their protospacer adjacent motif (PAM) requirements. We demonstrate a critical expansion of the targetable sequence space for a type II-A CRISPR-associated enzyme th...

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Bibliographic Details
Main Authors: Chatterjee, Pranam (Author), Lee, Jooyoung (Author), Nip, Lisa (Author), Koseki, Sabrina R. T. (Author), Tysinger, Emma (Author), Sontheimer, Erik J. (Author), Jacobson, Joseph (Author), Jakimo, Noah (Author)
Other Authors: Massachusetts Institute of Technology. Center for Bits and Atoms (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-28T13:47:51Z.
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