Mammalian germ cells are determined after PGC colonization of the nascent gonad

Mammalian primordial germ cells (PGCs) are induced in the embryonic epiblast, before migrating to the nascent gonads. In fish, frogs, and birds, the germline segregates even earlier, through the action of maternally inherited germ plasm. Across vertebrates, migrating PGCs retain a broad developmenta...

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Bibliographic Details
Main Authors: Nicholls, Peter K. (Author), Schorle, Hubert (Author), Naqvi, Sahin (Author), Hu, Yueh-Chiang (Author), Fan, Yuting (Author), Carmell, Michelle A. (Author), Page, David C. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences, 2020-05-07T14:20:52Z.
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