Nanotechnological strategies for engineering complex tissues

• Main Authors: Dvir, Tal (Author), Timko, Brian T. (Author), Kohane, Daniel S. (Author), Langer, Robert S (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
• Format: Article
• Language: English
• Published: Springer Nature America, Inc, 2020-05-05T14:34:27Z.
• Subjects: Article
• Online Access: Get fulltext

Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.
National Institutes of Health (U.S.) (Grant DE13023)
National Institutes of Health (U.S.) (Grant DE016516)
National Institutes of Health (U.S.) (Grant DEB006365)
National Institutes of Health (U.S.) (Grant R01GM073626)
National Science Foundation (U.S.) (Grant BES-0609182)