Synthesis of potent cytotoxic epidithiodiketopiperazines designed for derivatization

Synthesis of potent cytotoxic epidithiodiketopiperazines designed for derivatization

We describe our design, synthesis, and chemical study of a set of functional epidithiodiketopiperazines (ETPs) and evaluation of their activity against five human cancer cell lines. Our structure-activity relationship-guided substitution of ETP alkaloids offers versatile derivatization while maintai...

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Bibliographic Details
Main Authors:	Olsson, Chase Robert (Author), Payette, Joshua N. (Author), Cheah, Jaime (Author), Movassaghi, Mohammad (Author)
Other Authors:	Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format:	Article
Language:	English
Published:	American Chemical Society (ACS), 2020-04-14T20:01:23Z.
Subjects:	Article
Online Access:	Get fulltext

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