Real-time mortality prediction in the Intensive Care Unit

• Main Authors: Johnson, Alistair Edward William (Author), Mark, Roger G (Author)
• Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
• Format: Article
• Language: English
• Published: American Medical Informatics Association, 2019-12-04T22:41:19Z.
• Subjects: Article
• Online Access: Get fulltext

 Real-time prediction of mortality for intensive care unit patients has the potential to provide physicians with a simple and easily interpretable synthesis of patient acuity. Here we extract data from a random time during each patient's ICU stay. We believe this sampling scheme allows for the application of the model(s) across a future patient's entire ICU stay. The AUROC of a Gradient Boosting model was high (AUROC=0.920), even though no information about diagnosis or comorbid burden was utilized. We also compare models using data from the first 24 hours of a patient's stay against published severity of illness scores, and find the Gradient Boosting model greatly outperformed the frequently used Simplified Acute Physiology Score II (AUROC = 0.927 vs. 0.809). We nuance this performance with comparison to the literature, provide our interpretation, and discuss potential avenues for improvement.