A Developmental Switch in Microglial HDAC Function

A Developmental Switch in Microglial HDAC Function

The epigenetic mechanisms controlling microglia functions are largely unknown. In this issue of Immunity, Datta et al. (2018) uncover surprising and distinct effects of deleting the epigenetic regulators HDAC1 and HDAC2 during microglial development versus during the course of neurodegeneration.

Bibliographic Details
Main Authors: Mathys, Hansruedi (Author), Penney, Jay (Author), Tsai, Li-Huei (Author)
Other Authors: Picower Institute for Learning and Memory (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-11-15T18:15:14Z.
Subjects:
Article
Online Access:Get fulltext
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520 |a The epigenetic mechanisms controlling microglia functions are largely unknown. In this issue of Immunity, Datta et al. (2018) uncover surprising and distinct effects of deleting the epigenetic regulators HDAC1 and HDAC2 during microglial development versus during the course of neurodegeneration. 
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