Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity

Despite studies indicating the effects of IL-21 signaling in intestinal inflammation, its roles in intestinal homeostasis and infection are not yet clear. Here, we report potent effects of commensal microbiota on the phenotypic manifestations of IL-21 receptor deficiency. IL-21 is produced highly in...

Full description

Bibliographic Details
Main Authors: Cho, Hyeseon (Author), Jaime, Henrique (Author), de Oliveira, Rafael Pires (Author), Kang, Byunghyun (Author), Spolski, Rosanne (Author), Vaziri, Tina (Author), Myers, Timothy G. (Author), Thovarai, Vishal (Author), Shen, Zeli (Author), Fox, James G. (Author), Leonard, Warren J. (Author), Kelsall, Brian L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media, 2019-10-21T15:13:11Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items