Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thus enable novel treatment strategies with broad app...

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Main Authors: Novobrantseva, Tatiana I (Author), Borodovsky, Anna (Author), Wong, Jamie (Author), Klebanov, Boris (Author), Zafari, Mohammad (Author), Yucius, Kristina (Author), Querbes, William (Author), Ge, Pei (Author), Ruda, Vera M (Author), Milstein, Stuart (Author), Speciner, Lauren (Author), Duncan, Rick (Author), Barros, Scott (Author), Basha, Genc (Author), Cullis, Pieter (Author), Akinc, Akin (Author), Donahoe, Jessica S (Author), Narayanannair Jayaprakash, K (Author), Jayaraman, Muthusamy (Author), Bogorad, Roman (Author), Love, Kevin T (Author), Whitehead, Kathryn Ann (Author), Levins, Christopher G. (Author), Manoharan, Muthiah (Author), Swirski, Filip K (Author), Weissleder, Ralph (Author), Langer, Robert S (Author), Anderson, Daniel Griffith (Author), de Fougerolles, Antonin (Author), Nahrendorf, Matthias (Author), Koteliansky, Victor (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Harvard University- (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-08-23T15:00:03Z.
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