PKM2 is not required for pancreatic ductal adenocarcinoma

PKM2 is not required for pancreatic ductal adenocarcinoma

Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in human pancreatic cancer, and there have been conflicting reports on the association...

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Main Authors: Danai, Laura V (Author), Di Vizio, Dolores (Author), Hillis, Alissandra L. (Contributor), Lau, Allison N. (Contributor), Devoe, Camille X. (Contributor), Vander Heiden, Matthew G. (Contributor), Dayton, Talya Lucia (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Dayton, Talya L (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2018-11-05T15:33:43Z.
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