Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype

Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype

Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the phenotype remains brain specific is poorly understood. In this study, we used in vitro differentiation of human embryonic stem cells to monitor the...

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Main Authors: Omer Javed, Attya (Author), Muffat, Julien (Author), Su, Kuan-Chung (Author), Lungjangwa, Tenzin (Author), Aubourg, Patrick (Author), Li, Yun (Contributor), Cohen, Malkiel A (Contributor), Cheeseman, Iain M (Contributor), Jaenisch, Rudolf (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-10-22T16:28:56Z.
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