Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transformation, cancer survival, and resistance to chemotherapy. Discovering potent and selective Mcl-1 inhibitors that can relieve apoptotic blockades is thus...

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Bibliographic Details
Main Authors: Bird, Gregory H. (Author), Ryan, Jeremy A. (Author), Godes, Marina (Author), Pritz, Jonathan R. (Author), Letai, Anthony (Author), Walensky, Loren D. (Author), Rezaei Araghi, Raheleh (Contributor), Jenson, Justin Michael (Contributor), Grant, Robert A (Contributor), Keating, Amy E. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Keating, Amy E (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2018-10-15T17:25:06Z.
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