AMPK promotes tolerance to Ras pathway inhibition by activating autophagy

AMPK promotes tolerance to Ras pathway inhibition by activating autophagy

Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great promise in the clinic, but resistance remains a major challenge: 30% of tumors with pathway mutations do not respond to targeted inhibitors, and of the 70% that do respond, all eventually develop resista...

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Main Authors: Sanduja, S (Author), Feng, Y (Author), Reinhardt, F (Author), Halaban, R (Author), Mathis, Robert Austin (Contributor), Sokol, Ethan Samuel (Contributor), Gupta, Piyush (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-08-27T18:51:15Z.
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