Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein−Protein Interaction

Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein−Protein Interaction

Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired re...

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Main Authors: Sail, Vibhavari (Author), Rizzo, Alessandro A. (Author), Dash, Radha C. (Author), Ozen, Zuleyha (Author), Korzhnev, Dmitry M. (Author), Hadden, M. Kyle (Author), Chatterjee, Nimrat (Contributor), Walker, Graham C. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Walker, Graham C (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2018-08-22T20:11:18Z.
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