Resolving CNS mRNA Heterogeneity: Examining mRNA Alternative Polyadenylation at a Cell-Type-Specific Level

• Main Authors: Therrien, Martine (Author), Heiman, Myriam (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
• Format: Article
• Language: English
• Published: Elsevier BV, 2018-08-22T17:51:01Z.
• Subjects: Article
• Online Access: Get fulltext

Alternative polyadenylation often regulates mRNA isoform usage. In this issue of Neuron, Hwang et al. (2017) describe a powerful new cell-type-specific methodology, cTag-PAPERCLIP, which can be used to study alternative polyadenylation in the CNS. Keywords: alternative polyadenylation; cell type specificity; cTag-PAPERCLIP