Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Somatic mutations within noncoding genomic regions that aberrantly activate oncogenes have remained poorly characterized. Here we describe recurrent activating intronic mutations of LMO2, a prominent oncogene in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in P...

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Bibliographic Details
Main Authors: Rahman, Sunniyat (Author), Magnussen, Michael (Author), León, Theresa E. (Author), Farah, Nadine (Author), Li, Zhaodong (Author), Alapi, Krisztina Z. (Author), Mitchell, Rachel J. (Author), Naughton, Tom (Author), Fielding, Adele K. (Author), Pizzey, Arnold (Author), Bustraan, Sophia (Author), Popa, Teodora (Author), Pike-Overzet, Karin (Author), Garcia-Perez, Laura (Author), Gale, Rosemary E. (Author), Linch, David C. (Author), Staal, Frank J. T. (Author), Look, A. Thomas (Author), Mansour, Marc R. (Author), Abraham, Brian Joseph (Contributor), Allen, Christopher D (Contributor), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Richard Young (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: American Society of Hematology, 2018-08-06T17:53:41Z.
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