Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including genetic tumor syndromes, cancer, and obesity. However, the cell-intrinsic consequences of mTORC1 activation remain poorly defined. Through a combin...

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Main Authors: Düvel, Katrin (Author), Yecies, Jessica L. (Author), Menon, Suchithra (Author), Raman, Pichai (Author), Triantafellow, Ellen (Author), Ma, Qicheng (Author), Gorski, Regina (Author), Cleaver, Stephen (Author), MacKeigan, Jeffrey P. (Author), Finan, Peter M. (Author), Murphy, Leon O. (Author), Manning, Brendan D. (Author), Lipovsky, Alex (Contributor), Souza, Amanda (Contributor), Vander Heiden, Matthew G. (Contributor), Clish, Clary (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-07-12T17:04:03Z.
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