Mouse ooplasm confers context-specific reprogramming capacity

Mouse ooplasm confers context-specific reprogramming capacity

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear trans...

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Bibliographic Details
Main Authors: Chan, Michelle M (Author), Smith, Zachary D (Author), Egli, Dieter (Author), Regev, Aviv (Contributor), Meissner, Alexander (Author), Chan, Michelle Mei Wah (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-03T15:34:47Z.
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