IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment

IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment

Homeostatic programs balance immune protection and self-tolerance. Such mechanisms likely impact autoimmunity and tumor formation, respectively. How homeostasis is maintained and impacts tumor surveillance is unknown. Here, we find that different immune mononuclear phagocytes share a conserved stead...

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Main Authors: Nirschl, Christopher J. (Author), Suárez-Fariñas, Mayte (Author), Izar, Benjamin (Author), Dannenfelser, Ruth (Author), Tirosh, Itay (Author), Liu, Yong (Author), Zhu, Qian (Author), Devi, K. Sanjana P. (Author), Chau, David (Author), Rezaee, Melika (Author), Kim, Tae-Gyun (Author), Huang, Ruiqi (Author), Fuentes-Duculan, Judilyn (Author), Song-Zhao, George X. (Author), Gulati, Nicholas (Author), Lowes, Michelle A. (Author), King, Sandra L. (Author), Quintana, Francisco J. (Author), Lee, Young-suk (Author), Krueger, James G. (Author), Sarin, Kavita Y. (Author), Yoon, Charles H. (Author), Troyanskaya, Olga (Author), Anandasabapathy, Niroshana (Author), Prakadan, Sanjay (Contributor), Carroll, Shaina Laufer (Contributor), Regev, Aviv (Contributor), Shalek, Alexander K (Contributor), Garraway, Levi A. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Garraway, Levi (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-02T20:13:51Z.
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