Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation

Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation

Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved. Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions. Like cells of the blastocyst, t...

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Bibliographic Details
Main Authors: Sahakyan, Anna (Author), Kim, Rachel (Author), Chronis, Constantinos (Author), Sabri, Shan (Author), Bonora, Giancarlo (Author), Theunissen, Thorold W. (Author), Kuoy, Edward (Author), Langerman, Justin (Author), Clark, Amander T. (Author), Plath, Kathrin (Author), Jaenisch, Rudolf (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-06-26T13:29:21Z.
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