Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Forward genetic screens are powerful tools for the unbiased discovery and functional characterization of specific genetic elements associated with a phenotype of interest. Recently, the RNA-guided endonuclease Cas9 from the microbial CRISPR (clustered regularly interspaced short palindromic repeats)...

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Main Authors: Joung, Julia (Contributor), Konermann, Silvana M (Contributor), Gootenberg, Jonathan S (Contributor), Abudayyeh, Omar Osama (Contributor), Platt, Randall Jeffrey (Contributor), Brigham, Mark D (Contributor), Sanjana, Neville E (Contributor), Zhang, Feng (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2017-12-14T14:53:35Z.
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