PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in regulating anabolic metabolism. To determine whether PKM2 is required for tumor formation or growth, we generated mice with a conditional allele that abolishes PKM2 expression without disrupting PKM1 expression. PKM2 de...

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Main Authors: Li, Jie (Author), Sasaki, Mika (Author), Horner, James W (Author), Burga, Laura N (Author), Xie, Jianxin (Author), Jurczak, Michael J (Author), DePinho, Ronald A (Author), Clish, Clary B (Author), Kibbey, Richard G (Author), Wulf, Gerburg M (Author), Di Vizio, Dolores (Author), Mills, Gordon B (Author), Cantley, Lewis C (Author), Israelsen, William James (Contributor), Dayton, Talya L. (Contributor), Davidson, Shawn M. (Contributor), Fiske, Brian Prescott (Contributor), Hosios, Aaron Marc (Contributor), Bellinger, Gary (Contributor), Yu, Yimin (Contributor), Jacks, Tyler E. (Contributor), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-07-10T18:31:09Z.
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