Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

CRISPR/Cas9 derived from the bacterial adaptive immunity pathway is a powerful tool for genome editing, but the safety profiles of in vivo delivered Cas9 (including host immune responses to the bacterial Cas9 protein) have not been comprehensively investigated in model organisms. Nonalcoholic steato...

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Bibliographic Details
Main Authors: Wang, Dan (Author), Mou, Haiwei (Author), Li, Shaoyong (Author), Li, Yingxiang (Author), Hough, Soren (Author), Tran, Karen (Author), Li, Jia (Author), Sontheimer, Erik J. (Author), Weng, Zhiping (Author), Gao, Guangping (Author), Xue, Wen (Author), Yin, Hao (Contributor), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Mary Ann Liebert, 2017-07-07T15:35:20Z.
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