Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase

• Main Authors: Minnihan, Ellen Catherine (Contributor), Stubbe, JoAnne (Contributor), Nocera, Daniel G. (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Nocera, Daniel G (Contributor)
• Format: Article
• Language: English
• Published: American Chemical Society (ACS), 2017-06-30T19:17:44Z.
• Subjects: Article
• Online Access: Get fulltext

Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides (NDPs or NTPs where N = C, U, G, or A) to 2'-deoxynucleotides (dNDPs or dNTPs)[superscript 1] and are responsible for controlling the relative ratios and absolute concentrations of cellular dNTP pools. For this reason, RNRs play a major role in ensuring the fidelity of DNA replication and repair. RNRs are found in all organisms and are classified based on the metallocofactor used to initiate catalysis,[superscript 1] with the class Ia RNRs requiring a diferric-tyrosyl radical (Y•) cofactor.
National Institutes of Health (U.S.) (GM47274)
National Institutes of Health (U.S.) (GM29595)