Structural insights into LINC complexes

• Main Authors: Kutay, Ulrike (Author), Schwartz, Thomas (Contributor), Sosa, Brian A. (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Sosa-Alvarado, Brian Alexander (Contributor)
• Format: Article
• Language: English
• Published: Elsevier, 2017-06-27T19:28:54Z.
• Subjects: Article
• Online Access: Get fulltext

Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH)-peptide bearing proteins residing in the outer nuclear membrane directly bind and constitute the core of the LInkers of Nucleoskeleton and Cytoskeleton (LINC) complex. These connections appear critical for a growing number of biological processes and aberrations are implicated in a host of diverse diseases, including muscular dystrophies, cardiomyopathies, and premature aging. We discuss recent developments in this vibrant research area, particularly in context of first structural insights into LINC complexes reported in the past year.
National Institute of Neurological Disorders and Stroke (U.S.) (grant R21 NS075883)
Dystonia Medical Research Foundation