Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several t...

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Bibliographic Details
Main Authors: Peng, Jian (Contributor), Tucker, George Jay (Contributor), Leighton, Alexander T. (Contributor), Berger Leighton, Bonnie (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-06-22T22:54:34Z.
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