Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations

Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations

Recent drug discovery and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for precision medicine. However, drug resistance remains a major challenge as minor pre-existing resistant subpopulations are often found to be enriched at relapse. Current drug design h...

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Bibliographic Details
Main Authors: Sun, Daphne S. (Contributor), Dalin, Simona (Contributor), Hemann, Michael (Contributor), Lauffenburger, Douglas A (Contributor), Zhao, Boyang (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor), Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-06-12T13:57:13Z.
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