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|a Mo, Yiming
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Mo, Yiming
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|a Jensen, Klavs F
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|a Jensen, Klavs F
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|a A miniature CSTR cascade for continuous flow of reactions containing solids
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|b Royal Society of Chemistry, The,
|c 2017-05-19T15:51:24Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/109210
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|a Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements of the CSTR cascade reveal nearly ideal CSTR mixing behavior of the individual units. Consistency of experimental and predicted conversions of a Diels-Alder reaction further confirms the CSTR performance. Two solid-forming reactions, (i) glyoxal reacting with cyclohexylamine to form N,N'-dicyclohexylethylenediimine, (ii) sulfonylation of 2-octanol with methanesulfonyl chloride, demonstrate the ability of the reactor cascade to transport solid particles continuously for hours without significant signs of clogging.
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|a en_US
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|a Article
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|t Reaction Chemistry & Engineering
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