Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide

Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide

We report the discovery of HD5-CD, an unprecedented C[subscript 2]-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys[superscript II]-Cys[superscript I...

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Main Authors: Ziarek, Joshua J. (Author), Wagner, Gerhard (Author), Wommack, Andrew (Contributor), Tomaras, Jill M (Contributor), Chileveru, Haritha reddy (Contributor), Zhang, Yunfei (Contributor), Nolan, Elizabeth Marie (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society, 2017-05-16T15:26:43Z.
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