The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior

The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior

During tumor progression, alternative splicing gives rise to different Mena protein isoforms. We analyzed how Mena11a, an isoform enriched in epithelia and epithelial-like cells, affects Mena-dependent regulation of actin dynamics and cell behavior. While other Mena isoforms promote actin polymeriza...

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Bibliographic Details
Main Authors: Condeelis, John S. (Author), Balsamo, Michele (Contributor), Mondal, Chandrani (Contributor), Carmona, Guillaume (Contributor), McClain, Leslie Marie (Contributor), Riquelme, Daisy Noelia (Contributor), Tadros, Jenny (Contributor), Ma, Duanduan (Contributor), Vasile, Eliza (Contributor), Lauffenburger, Douglas A (Contributor), Gertler, Frank (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-03-29T14:09:18Z.
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