Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages

Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages

The extracellular serine protease inhibitor serpinE2 is overexpressed in breast cancer and has been shown to foster metastatic spread. Here, we investigated the hypothesis that serpinE2 creates tumor-promoting conditions in the tumor microenvironment (TME) by affecting extracellular matrix remodelin...

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Bibliographic Details
Main Authors: Smirnova, Tatiana (Author), Bonapace, Laura (Author), MacDonald, Gwen (Author), Kondo, Shunya (Author), Wyckoff, Jeffrey (Contributor), Ebersbach, Hilmar (Author), Fayard, Bérengère (Author), Doelemeyer, Arno (Author), Coissieux, Marie-May (Author), Heideman, Marinus R. (Author), Bentires-Alj, Mohamed (Author), Hynes, Nancy E. (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Impact Journals/National Center for Biotechnology Information (U.S.), 2017-03-24T15:48:20Z.
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