CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
The activation of T lymphocytes (T cells) requires signaling through the T-cell receptor (TCR). The role of the coreceptor molecules, CD4 and CD8, is not clear, although they are thought to augment TCR signaling by stabilizing interactions between the TCR and peptide-major histocompatibility (pMHC)...
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Bibliographic Details
| Main Authors: |
Davis, M. M.
(Author),
Artyomov, Maxim N.
(Contributor),
Lis, Mieszko
(Contributor),
Chakraborty, Arup K
(Contributor),
Devadas, Srinivas
(Contributor) |
|---|
| Other Authors: |
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
(Contributor),
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
(Contributor),
Massachusetts Institute of Technology. Department of Biological Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Chemical Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Chemistry
(Contributor),
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
(Contributor),
Ragon Institute of MGH, MIT and Harvard
(Contributor) |
|---|
| Format: | Article
|
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| Language: | English |
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| Published: |
National Academy of Sciences (U.S.),
2017-03-22T15:37:27Z.
|
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| Subjects: | |
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| Online Access: | Get fulltext
|
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