RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, when present in RNA molecules, diminish the magnitude of these...

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Bibliographic Details
Main Authors:	Durbin, Ann Fiegen (Author), Wang, Chen (Author), Marcotrigiano, Joseph (Author), Gehrke, Lee (Contributor)
Other Authors:	Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format:	Article
Language:	English
Published:	American Society for Microbiology, 2017-03-10T19:08:38Z.
Subjects:	Article
Online Access:	Get fulltext

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