Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural n...

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Main Authors: Kim, Minkyu (Contributor), Chen, Wesley George (Contributor), Ribbeck, Katharina (Contributor), Olsen, Bradley D (Contributor), Kang, Jeon Woong (Contributor), Glassman, Matthew J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Laser Biomedical Research Center (Contributor), Glassman, Matthew James (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2017-02-02T20:31:19Z.
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Online Access:Get fulltext
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100 1 0 |a Kim, Minkyu  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biological Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemical Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Laser Biomedical Research Center  |e contributor 
100 1 0 |a Kim, Minkyu  |e contributor 
100 1 0 |a Chen, Wesley George  |e contributor 
100 1 0 |a Glassman, Matthew James  |e contributor 
100 1 0 |a Ribbeck, Katharina  |e contributor 
100 1 0 |a Olsen, Bradley D  |e contributor 
100 1 0 |a Kang, Jeon Woong  |e contributor 
700 1 0 |a Chen, Wesley George  |e author 
700 1 0 |a Ribbeck, Katharina  |e author 
700 1 0 |a Olsen, Bradley D  |e author 
700 1 0 |a Kang, Jeon Woong  |e author 
700 1 0 |a Glassman, Matthew J.  |e author 
245 0 0 |a Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport 
260 |b Wiley Blackwell,   |c 2017-02-02T20:31:19Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/106834 
520 |a Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies. 
520 |a United States. Defense Threat Reduction Agency (Grant HDTRA1-13-1-0038) 
520 |a National Institutes of Health (U.S.) (Grant 5-T32-GM008834) 
520 |a National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant P41EB015871-28) 
520 |a MIT Skoltech Initiative 
546 |a en_US 
655 7 |a Article 
773 |t Advanced Materials