Identification and characterization of essential genes in the human genome

Identification and characterization of essential genes in the human genome

Large-scale genetic analysis of lethal phenotypes has elucidated the molecular underpinnings of many biological processes. Using the bacterial clustered regularly interspaced short palindromic repeats (CRISPR) system, we constructed a genome-wide single-guide RNA (sgRNA) library to screen for genes...

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Bibliographic Details
Main Authors: Hughes, N. W. (Author), Wang, Tim (Contributor), Birsoy, Kivanc (Contributor), Krupczak, Kevin M. (Contributor), Post, Yorick (Contributor), Lander, Eric Steven (Contributor), Sabatini, David (Contributor), Wei, Jenny J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Wei, Jenny J (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-01-05T16:46:34Z.
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