Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

Glucose and amino acids are key nutrients supporting cell growth. Amino acids are imported as monomers, but an alternative route induced by oncogenic KRAS involves uptake of extracellular proteins via macropinocytosis and subsequent lysosomal degradation of these proteins as a source of amino acids....

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Bibliographic Details
Main Authors: Kamphorst, J. J. (Author), Nofal, M. (Author), Commisso, C. (Author), Hackett, S. R. (Author), Lu, W. (Author), Grabocka, E. (Author), Miller, G. (Author), Drebin, J. A. (Author), Bar-Sagi, D. (Author), Thompson, C. B. (Author), Rabinowitz, J. D. (Author), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2016-12-14T21:07:35Z.
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Online Access:Get fulltext

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