Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

The balance between oxidative and non-oxidative glucose metabolism is essential for a number of pathophysiological processes. By deleting enzymes that affect aerobic glycolysis with different potencies, we examine how modulating glucose metabolism specifically affects hematopoietic and leukemic cell...

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Main Authors: Wang, Ying-Hua (Author), Lee, Dongjun (Author), Yu, Vionnie W.C (Author), Jeanson, Nathaniel T (Author), Clish, Clary B (Author), Cantley, Lewis C (Author), Scadden, David T (Author), Israelsen, William James (Contributor), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-14T20:44:52Z.
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