Refraction data survey: 2nd generation correlation of myopia

The objective herein is to provide refraction data, myopia progression rate, prevalence, and 1st and 2nd generation correlations, relevant to whether myopia is random or inherited. First- and second-generation ocular refraction data are assembled from N = 34 families, average of 2.8 children per fam...

Full description

Bibliographic Details
Main Authors: Greene, Peter R. (Author), Medina, Antonio (Contributor)
Other Authors: Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor)
Format: Article
Language:English
Published: Springer Netherlands, 2016-12-01T21:38:07Z.
Subjects:
Online Access:Get fulltext
LEADER 01876 am a22001813u 4500
001 105510
042 |a dc 
100 1 0 |a Greene, Peter R.  |e author 
100 1 0 |a Massachusetts Institute of Technology. Research Laboratory of Electronics  |e contributor 
100 1 0 |a Medina, Antonio  |e contributor 
700 1 0 |a Medina, Antonio  |e author 
245 0 0 |a Refraction data survey: 2nd generation correlation of myopia 
260 |b Springer Netherlands,   |c 2016-12-01T21:38:07Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/105510 
520 |a The objective herein is to provide refraction data, myopia progression rate, prevalence, and 1st and 2nd generation correlations, relevant to whether myopia is random or inherited. First- and second-generation ocular refraction data are assembled from N = 34 families, average of 2.8 children per family. From this group, data are available from N = 165 subjects. Inter-generation regressions are performed on all the data sets, including correlation coefficient r, and myopia prevalence [%]. Prevalence of myopia is [M] = 38.5 %. Prevalence of high myopes with |R| >6 D is [M−] = 20.5 %. Average refraction is <R> = −1.84 D ± 3.22 (N = 165). For the high myopes, |R| >6 D, prevalence for the parents is [M−] = 25 %, for the 2nd generation [M−] = 16.5 %. Average myopia level for the high myopes, both generations, is <S> = −7.52 D ± 1.31 D (N = 33). Regression parameters are calculated for all the data sets, yielding correlation coefficients in the range r = 0.48-0.72 for some groups of myopes and high myopes, fathers to daughters, and mothers to sons. Also of interest, some categories show essentially no correlation, −0.20 < r < 0.20, indicating that the refractive errors occur randomly. Time series results show myopia diopter rates = −0.50 D/year. 
546 |a en 
655 7 |a Article 
773 |t International Ophthalmology