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105334 |
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|a Ocampo, Charles Edward
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|a Massachusetts Institute of Technology. Department of Chemistry
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|a Jamison, Timothy F
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|a Ocampo, Charles Edward
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|a Lee, Doris
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|a Jamison, Timothy F
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|a Lee, Doris
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|a Jamison, Timothy F
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|a Selective Lewis Acid Catalyzed Assembly of Phosphonomethyl Ethers: Three-Step Synthesis of Tenofovir
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|b American Chemical Society (ACS),
|c 2016-11-15T20:00:07Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/105334
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|a Described herein is a novel Lewis acid catalyzed rearrangement-coupling of oxygen heterocycles and bis(diethylamino)chlorophosphine that provides direct formation of the phosphonomethyl ether functionality found in several important antiretroviral agents. A wide range of dioxolanes and 1,3-dioxanes may be employed, furnishing the desired products in good yield. The utility of this method is demonstrated in a novel synthesis of tenofovir, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B.
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|a Bill & Melinda Gates Foundation ("Medicines for All" Initiative)
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|a Natural Sciences and Engineering Research Council of Canada (NSERC Postdoctoral Fellowship)
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|a en_US
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|a Article
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|t Organic Letters
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