SMC complexes link gene expression and genome architecture

• Main Authors: Dowen, Jill M. (Author), Young, Richard A. (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
• Format: Article
• Language: English
• Published: Elsevier, 2016-08-11T19:51:40Z.
• Subjects: Article
• Online Access: Get fulltext

The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.
National Institutes of Health (U.S.) (Ruth L Kirschstein National Research Service Award (CA168263-01A1))
National Cancer Institute (U.S.)
National Institutes of Health (U.S.) (NIH grant HG002668)