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103898 |
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|a dc
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|a Olenchock, Benjamin
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Olenchock, Benjamin
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|a Vander Heiden, Matthew G.
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|a Vander Heiden, Matthew G.
|e author
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|a Pyruvate as a Pivot Point for Oncogene-Induced Senescence
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|b Elsevier,
|c 2016-08-11T16:08:04Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/103898
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|a Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
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|a en_US
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|a Article
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|t Cell
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