Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain

We describe a homozygous copy-number variant that disrupts the function of Dock2 in a commercially available C57BL/6 mouse strain that is widely used for backcrossing. This Dock2 allele was presumed to have spontaneously arisen in a colony of Irf5 knockout mice. We discovered that this allele has ac...

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Bibliographic Details
Main Authors: Mahajan, Vinay S (Author), Demissie, Ezana (Contributor), Mattoo, Hamid (Contributor), Viswanadham, Vinay (Contributor), Varki, Ajit (Author), Morris, Robert (Contributor), Pillai, Shiv (Contributor), Mahajan, Vinay S. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-07-18T17:02:35Z.
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