Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs

Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs

Background Systemic risk factors and local hemodynamic factors both contribute to coronary atherosclerosis, but their possibly synergistic inter-relationship remains unknown. The purpose of this natural history study was to investigate the combined in-vivo effect of varying levels of systemic hyperc...

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Main Authors: Koskinas, Konstantinos C. (Contributor), Chatzizisis, Yiannis S. (Contributor), Coskun, Ahmet U. (Author), Baker, Aaron B. (Contributor), Jarolim, Petr (Author), Antoniadis, Antonios (Author), Edelman, Elazer R. (Contributor), Stone, Peter H. (Author), Feldman, Charles L. (Author), Papafaklis, Michail (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Harvard University- (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-04-28T12:51:11Z.
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