Bacterial infection remodels the DNA methylation landscape of human dendritic cells

Bacterial infection remodels the DNA methylation landscape of human dendritic cells

DNA methylation is an epigenetic mark thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendritic cells (DCs) with a live pathogenic bacteria is associated with rapid and active demethylation at thousa...

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Bibliographic Details
Main Authors: Pacis, Alain (Author), Tailleux, Ludovic (Author), Morin, Alexander M. (Author), Lambourne, John (Author), MacIsaac, Julia L. (Author), Yotova, Vania (Author), Dumaine, Anne (Author), Danckaert, Anne (Author), Luca, Francesca (Author), Grenier, Jean-Christophe (Author), Hansen, Kasper D. (Author), Gicquel, Brigitte (Author), He, Chuan (Author), Tung, Jenny (Author), Pastinen, Tomi (Author), Kobor, Michael S. (Author), Pique-Regi, Roger (Author), Gilad, Yoav (Author), Barreiro, Luis B. (Author), Pai, Athma A. (Contributor), Yu, Miao, Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2016-04-19T15:24:40Z.
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