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101284 |
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|a dc
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|a Cooke, Brian M.
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Lim, Daniel Cham-Chin
|e contributor
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|a Saeij, Jeroen
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|a Doerig, Christian
|e author
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|a Lim, Daniel Cham-Chin
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|a Saeij, Jeroen
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|a Toxoplasma and Plasmodium protein kinases: Roles in invasion and host cell remodelling
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|b Elsevier,
|c 2016-02-26T02:34:15Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/101284
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|a Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).
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|a American Heart Association (0835099N)
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|a Massachusetts Life Sciences Center (New Investigator Award)
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|a Singapore-MIT Alliance for Research and Technology
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|a Pew Charitable Trusts
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|a New England Regional Center of Excellence (Developmental Grant)
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|a National Institutes of Health (U.S.) (RO1-AI080621)
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|a Merck Research Laboratories (Postdoctoral Fellowship)
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|a Massachusetts Institute of Technology. Department of Biology
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|a en_US
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|a Article
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|t International Journal for Parasitology
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