Identification of drug resistance mutations in HIV from constraints on natural evolution

Identification of drug resistance mutations in HIV from constraints on natural evolution

Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretro...

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Bibliographic Details
Main Authors: Barton, John P. (Contributor), Kardar, Mehran (Contributor), Butler, Thomas Charles (Author), Chakraborty, Arup K (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Butler, Thomas C. (Contributor), Chakraborty, Arup K. (Contributor)
Format: Article
Language:English
Published: American Physical Society, 2016-02-22T16:14:26Z.
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